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Science 7 July 1978:
Vol. 201. no. 4350, pp. 65 - 67
DOI: 10.1126/science.663638
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Articles

Science, Vol 201, Issue 4350, 65-67
Copyright © 1978 by American Association for the Advancement of Science

articles

6-Mercaptopurine treatment of pregnant mice: effects on second and third generations

TJ Reimers and PM Sluss

The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)