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Science 19 May 1978:
Vol. 200. no. 4343, pp. 773 - 775
DOI: 10.1126/science.205952
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Articles

Science, Vol 200, Issue 4343, 773-775
Copyright © 1978 by American Association for the Advancement of Science

articles

Collagenase immunolocalization in cultures of rheumatoid synovial cells

DE Woolley, ED Harris Jr, CL Mainardi, and CE Brinckerhoff

Cultures of rheumatoid synovial cells that have been enzymatically dissociated and are adherent to a culture vessel are morphologically heterogeneous. When these cells are cultured on a collagenous substrate for 2 to 6 days at 37 degrees C in serum-free medium, they produce collagenase. A monospecific antibody to human collagenase has localized the enzyme extracellularly around cytoplasmic extensions of dendritic cells and intracellularly within a few macrophage-like and fibroblast-like cells.


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