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Science 5 May 1978:
Vol. 200. no. 4341, pp. 563 - 565
DOI: 10.1126/science.200.4341.563
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Articles

(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity

ERIK DE CLERCQ 1, JOHAN DESCAMPS 1, PIERRE DE SOMER 1, and ANTONÍN HOLYacute 2

1 Rega Institute for Medical Research, University of Leuven, B-3000 Leuven, Belgium
2 Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague

(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.

Submitted on January 18, 1978


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of S-Adenosylhomocysteine Hydrolase by Acyclic Sugar Adenosine Analogue D-Eritadenine. CRYSTAL STRUCTURE OF S-ADENOSYLHOMOCYSTEINE HYDROLASE COMPLEXED WITH D-ERITADENINE.
Y. Huang, J. Komoto, Y. Takata, D. R. Powell, T. Gomi, H. Ogawa, M. Fujioka, and F. Takusagawa (2002)
J. Biol. Chem. 277, 7477-7482
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Vaccinia Virus Inhibitors as a Paradigm for the Chemotherapy of Poxvirus Infections.
E. De Clercq (2001)
Clin. Microbiol. Rev. 14, 382-397
   Abstract »    Full Text »    PDF »
Molecular Targets for Antiviral Agents.
E. De Clercq (2001)
J. Pharmacol. Exp. Ther. 297, 1-10
   Abstract »    Full Text »


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