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Science 5 May 1978:
Vol. 200. no. 4341, pp. 554 - 556
DOI: 10.1126/science.205950
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Articles

Science, Vol 200, Issue 4341, 554-556
Copyright © 1978 by American Association for the Advancement of Science

articles

Chemotactic antibody

MA Isturiz, AL Sandberg, E Schiffmann, SM Wahl, and AL Notkins

Antibody of the immunoglobulin G class to herpes simplex virus and antibody of the immunoglobulin M class to sheep red blood cells were coupled to the synthetic peptide formylmethionylleucylphenylalanine (fMet-Leu-Phe), which is chemotactic for both mononuclear and polymorphonuclear leukocytes. The resulting molecules were chemotactic and retained their antigen-binding activity. When antibodies coupled to fMet-Leu-Phe were incubated with antigen, the resulting immune complexes were also chemotactic. Chemotactic antibody may provide a potent means of enhancing the migration of inflammatory cells to specific sites.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)