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Science 5 May 1978:
Vol. 200. no. 4341, pp. 543 - 545
DOI: 10.1126/science.644315
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Articles

Science, Vol 200, Issue 4341, 543-545
Copyright © 1978 by American Association for the Advancement of Science

articles

Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells

S Wolff and B Rodin

Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chromosomes in the assessment of the effects of low levels of genotoxic agents.
S. Wolff (1998)
Human and Experimental Toxicology 17, 625-632
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Sister chromatid exchanges in human lymphocytes after exposure to diagnostic ultrasound.
D Liebeskind, R Bases, F Mendez, F Elequin, and M Koenigsberg (1979)
Science 205, 1273-1275
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Genetic effects of impure and pure saccharin in yeast.
C. Moore and A Schmick (1979)
Science 205, 1007-1010
   Abstract »    PDF »


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