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Science 5 May 1978:
Vol. 200. no. 4341, pp. 537 - 539
DOI: 10.1126/science.644312
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Articles

Science, Vol 200, Issue 4341, 537-539
Copyright © 1978 by American Association for the Advancement of Science

articles

Fluorinated molecule as a tracer: difluoroserotonin in human platelets mapped by electron energy-loss spectroscopy

JL Costa, DC Joy, DM Maher, KL Kirk, and SW Hui

The intracellular distribution of fluorine has been delineated in human platelets incubated with 4,6-difluoroserotonin, utilizing a scanning-transmission electron microscope equipped with an energy-loss spectrometer. Discrete intracellular structures corresponding in location to dense bodies contained high concentrations of fluorine. Electron energy-loss spectroscopy, which apparently can detect less than 10(-20) gram of fluorine in an area of 10 square nonometers, can thus localize fluorinated tracer molecules with biological activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interfacial properties of most monofluorinated bile acids deviate markedly from the natural congeners: studies with the Langmuir-Pockels surface balance.
J. M. Kauffman, R. Pellicciari, and M. C. Carey (2005)
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Fluorocholesterols, in contrast to hydroxycholesterols, exhibit interfacial properties similar to cholesterol.
J. M. Kauffman, P. W. Westerman, and M. C. Carey (2000)
J. Lipid Res. 41, 991-1003
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Inner-Shell Electron Spectroscopy for Microanalysis.
D. C. Joy and D. M. Maher (1979)
Science 206, 162-168
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Effect of fluorine substitution on the agonist specificity of norepinephrine.
D Cantacuzene, K. Kirk, D. McCulloh, and C. Creveling (1979)
Science 204, 1217-1219
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