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Science 28 April 1978:
Vol. 200. no. 4340, pp. 456 - 458
DOI: 10.1126/science.644310
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Articles

Science, Vol 200, Issue 4340, 456-458
Copyright © 1978 by American Association for the Advancement of Science

articles

Norepinephrine in chronic paranoid schizophrenia: above-normal levels in limbic forebrain

IJ Farley, KS Price, E McCullough, JH Deck, W Hordynski, and O Hornykiewicz

In postmortem examination of brains of four patients with chronic paranoid schizophrenia, above-normal norepinephrine levels were measured in the ventral septum, the bed nucleus of the stria terminalis, the nucleus accumbens, and the mammillary bodies. No changes were detected in other limbic forebrain regions, including the hypothalamus and the medial olfactory (preoptic) area. The results point to the possibility of a malfunction of limbic noradrenergic mechanisms in schizophrenia, especially the paranoid variety.


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