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Science 28 April 1978:
Vol. 200. no. 4340, pp. 449 - 451
DOI: 10.1126/science.565533
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Articles

Science, Vol 200, Issue 4340, 449-451
Copyright © 1978 by American Association for the Advancement of Science

articles

Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates

B Tabakoff, J Yanai, and RF Ritzmann

Mice treated with 6-hydroxydopamine before they were chronically fed phenobarbital did not develop functional barbiturate tolerance, measured by duration of the loss of righting reflex and hypothermia. Injection of 6-hydroxydopamine caused significant depletion of brain norepinephrine, while brain dopamine levels were not significantly depleted. Intact brain noradrenergic systems seem to be necessary for developing tolerance to the hypnotic and hypothermic effects of the barbiturates.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)