Science, Vol 200, Issue 4339, 337-339
Copyright © 1978 by American Association for the Advancement of Science
Neurotrophic protein regulates muscle acetylcholinesterase in culture
TH Oh
and
GJ Markelonis
Skeletal muscles lose acetylcholinesterase in culture as a result of denervation. A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle. These results indicate that trophic regulation of muscle acetylcholinesterase might be mediated by a protein produced by nerves.