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Science 21 April 1978:
Vol. 200. no. 4339, pp. 337 - 339
DOI: 10.1126/science.635593

Articles

Science, Vol 200, Issue 4339, 337-339
Copyright © 1978 by American Association for the Advancement of Science


articles

Neurotrophic protein regulates muscle acetylcholinesterase in culture

TH Oh and GJ Markelonis

Skeletal muscles lose acetylcholinesterase in culture as a result of denervation. A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle. These results indicate that trophic regulation of muscle acetylcholinesterase might be mediated by a protein produced by nerves.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)