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Science 21 April 1978:
Vol. 200. no. 4339, pp. 325 - 327
DOI: 10.1126/science.635590
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Articles

Science, Vol 200, Issue 4339, 325-327
Copyright © 1978 by American Association for the Advancement of Science

articles

Aflatoxicol: major aflatoxin B1 metabolite in rat plasma

ZA Wong and DP Hsieh

Aflatoxicol, a carcinogenic metabolite of the foodborne carcinogen aflatoxin B1 previously known only as a bioreduction product in vitro, was identified as the major aflatoxin metabolite in the plasma of Sprague-Dawley rats, a susceptible species, that had been doses orally or intravenously with aflatoxin B1 labeled with carbon-14. Alfatoxicol, however, was not detected in the plasma of similarly dosed mice and monkeys, which are both resistant to aflatoxin B1-induced cardinogenesis. The formation of aflatoxicol both in vitro and in vivo may be an indicatory of species sensitivity to aflatoxin-induced carcinogenesis and may be useful in the prediction of human susceptibility.


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