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Science 21 April 1978:
Vol. 200. no. 4339, pp. 317 - 318
DOI: 10.1126/science.635588
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Articles

Science, Vol 200, Issue 4339, 317-318
Copyright © 1978 by American Association for the Advancement of Science

articles

3-Methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in urine of humans with hypertension

RK Saran, RC Sahuja, NN Gupta, M Hasan, KP Bhargava, K Shanker, and K Kishor

3-Methoxy-4-hydroxyphenylglycol (MHPG) was measured in lumbar spinal fluid of 20 subjects with hypertension of varied etiology and severity. There was a significant correlation between the concentration of MHPG and the severity of hypertension. However, changes in the concentration of vanillylmandelic acid in the urine of these subjects were insignificant. In six subjects, administration of clonidine or alpha-methyldopa, two centrally acting antihypertensive drugs, was associated with a significant lowering of MHPG concentrations. These data support the hypothesis that central catecholamines are involved in clinical hypertension.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Essential hypertension: central and peripheral norepinephrine.
C. Lake, H. Gullner, R. Polinsky, M. Ebert, M. Ziegler, and F. Bartter (1981)
Science 211, 955-957
   Abstract »    PDF »
Specific and sensitive radioimmunoassay for 3-methoxy-4-hydroxyphenylethyleneglycol (MOPEG).
T. Keeton, H Krutzsch, and W Lovenberg (1981)
Science 211, 586-588
   Abstract »    PDF »


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