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Science 21 April 1978:
Vol. 200. no. 4339, pp. 312 - 314
DOI: 10.1126/science.635586
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Articles

Science, Vol 200, Issue 4339, 312-314
Copyright © 1978 by American Association for the Advancement of Science

articles

delta9-Tetrahydrocannabinol and 17beta-estradiol bind to different macromolecules in estrogen target tissues

AB Okey and GP Bondy

delta9-Tetrahydrocannabinol (delta9-THC), added to the limit of its solubility, did not compete with tritiated 17beta-estradiol for binding to estrogen receptor sites in mouse mammary or uterine cytosols. On sucrose density gradients of low-ionic strength, mammary cytosol labeled with [3H]estradiol exhibited a binding peak near the "8S" region typical of estrogen receptor whereas in cytosol labeled with delta9-[3H]THC binding was limited to the nonspecific 4- to 5S region. Differences in sedimentation properties and reciprocal competition studies strongly refute previous claims that delta-9-THC binds to estrogen receptor and that by so doing it directly acts as an estrogen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI.
A. B. Okey (2007)
Toxicol. Sci. 98, 5-38
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Science. ISSN 0036-8075 (print), 1095-9203 (online)