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Science 31 March 1978:
Vol. 199. no. 4336, pp. 1451 - 1453
DOI: 10.1126/science.204016
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Articles

Science, Vol 199, Issue 4336, 1451-1453
Copyright © 1978 by American Association for the Advancement of Science

articles

Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication

JL Barker, JH Neale, TG Smith Jr, and RL Macdonald

Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action of opiate peptide functionally distinct from the conventional neurotransmitter class of operation.


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AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium.
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Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro.
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Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons.
J. Vincent and J. Barker (1979)
Science 205, 1409-1412
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Enkephalin-containing neurons visualized in spinal cord cell cultures.
J. Neale, J. Barker, G. Uhl, and S. Snyder (1978)
Science 201, 467-469
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