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Science 31 March 1978:
Vol. 199. no. 4336, pp. 1441 - 1442
DOI: 10.1126/science.415366
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Articles

Science, Vol 199, Issue 4336, 1441-1442
Copyright © 1978 by American Association for the Advancement of Science

articles

B lymphocyte antigens in sicca syndrome

HM Moutsopoulos, TM Chused, AH Johnson, B Khudsen, and DL Mann

All individuals tested in this study with sicca syndrome, a human autoimmune disease, bear two immunologically distinct and genetically unrelated B lymphocyte antigens that appear similar to the immune response associated (Ia) antigens of the mouse. The genes coding for these two antigens are present in only 37 and 24 percent of normal controls. In animal models Ia antigen genes are closely linked to immune response genes. Our findings suggest that two such genes may be required for the development of sicca syndrome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Waldenstrom's Macroglobulinemia and Autoimmune Disease in a Family.
W. A. BLATTNER, J. E. GARBER, D. L. MANN, E. A. McKEEN, R. HENSON, D. B. McGUIRE, W. B. FISHER, A. W. BAUMAN, L. R. GOLDIN, and J. F. FRAUMENI Jr. (1980)
Ann Intern Med 93, 830-832
   Abstract »    PDF »
Dermatitis Herpetiformis: The Skin and the Gut.
S. I. KATZ, R. P. HALL III, T. J. LAWLEY, and W. STROBER (1980)
Ann Intern Med 93, 857-874
   Abstract »    PDF »
Sjogren's Syndrome (Sicca Syndrome): Current Issues.
H. M. MOUTSOPOULOS, T. M. CHUSED, D. L. MANN, J. H. KLIPPEL, A. S. FAUCI, M. M. FRANK, T. J. LAWLEY, and M. I. HAMBURGER (1980)
Ann Intern Med 92, 212-226
   Abstract »    PDF »
Allergy and Immunology: An Annotated Bibliography of Recent Literature: References to Journal Articles and Other Papers.
ALLERGY AND IMMUNOLOGY COMMITTEE (1979)
Ann Intern Med 90, 135-139
   Abstract »    PDF »
Increased Risk of Lymphoma in Sicca Syndrome.
S. S. KASSAN, T. L. THOMAS, H. M. MOUTSOPOULOS, R. HOOVER, R. P. KIMBERLY, D. R. BUDMAN, J. COSTA, J. L. DECKER, and T. M. CHUSED (1978)
Ann Intern Med 89, 888-892
   Abstract »    PDF »


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