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Science 24 March 1978:
Vol. 199. no. 4335, pp. 1349 - 1350
DOI: 10.1126/science.628844
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Articles

Science, Vol 199, Issue 4335, 1349-1350
Copyright © 1978 by American Association for the Advancement of Science

articles

Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture

T Papayannopoulou, B Nakamoto, J Buckley, S Kurachi, PE Nute, and G Stamatoyannopoulos

Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta.
R. M. Bohmer, T. A. Campbell, and D. W. Bianchi (2000)
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Altered Hematopoiesis in Murine Sickle Cell Disease.
M.-J. Blouin, M. E. De Paepe, and M. Trudel (1999)
Blood 94, 1451-1459
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Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics.
T Papayannopoulou, A Torrealba de Ron, R Veith, G Knitter, and G Stamatoyannopoulos (1984)
Science 224, 617-619
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