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Science 24 March 1978:
Vol. 199. no. 4335, pp. 1342 - 1345
DOI: 10.1126/science.204011
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Articles

Science, Vol 199, Issue 4335, 1342-1345
Copyright © 1978 by American Association for the Advancement of Science

articles

Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor

JE Horton, FH Wezeman, and KE Kuettner

A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)