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Science 17 March 1978:
Vol. 199. no. 4334, pp. 1231 - 1233
DOI: 10.1126/science.204008
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Articles

Science, Vol 199, Issue 4334, 1231-1233
Copyright © 1978 by American Association for the Advancement of Science

articles

Opiate receptors for behavioral analgesia resemble those related to the depression of spinal nociceptive neurons

TL Yaksh

With naloxone as antagonist, a dose-ratio analysis of the depression by morphine of nociceptive neurons in the spinal cord reveals that this opiate depression of single unit activity has the same pharmacological properties as observed with morphine analgesia. This suggests that the opiate receptor, mediating the observed cellular depression, and those mediating analgesia are presumably the same.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)