Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 March 1978:
Vol. 199. no. 4333, pp. 1093 - 1095
DOI: 10.1126/science.343250
Prev | Table of Contents | Next

Articles

Science, Vol 199, Issue 4333, 1093-1095
Copyright © 1978 by American Association for the Advancement of Science

articles

Endorphins: naloxone fails to alter experimental pain or mood in humans

P Grevert and A Goldstein

In 30 human subjects, experimental pain was produced by either ischemia or cold-water immersion. In a double-blind procedure, intravenous doses of up to 10 milligrams of naloxone hydrochloride in saline were indistinguishable from similarly administered saline alone. There were no effects on subjective pain ratings, finger plethysmograph recordings, or responses to mood-state questionnaires. These laboratory procedures do not activate any functionally significant pain-attenuating or mood-altering effect of endorphins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Endomorphin System and Its Evolving Neurophysiological Role.
J. Fichna, A. Janecka, J. Costentin, and J.-C. Do Rego (2007)
Pharmacol. Rev. 59, 88-123
   Abstract »    Full Text »    PDF »
FMRI Measurement of CNS Responses to Naloxone Infusion and Subsequent Mild Noxious Thermal Stimuli in Healthy Volunteers.
M. C. Borras, L. Becerra, A. Ploghaus, J. M. Gostic, A. DaSilva, R. G. Gonzalez, and D. Borsook (2004)
J Neurophysiol 91, 2723-2733
   Abstract »    Full Text »    PDF »
Postsynaptic Signaling via the {micro}-Opioid Receptor: Responses of Dorsal Horn Neurons to Exogenous Opioids and Noxious Stimulation.
J. A. Trafton, C. Abbadie, K. Marek, and A. I. Basbaum (2000)
J. Neurosci. 20, 8578-8584
   Abstract »    Full Text »    PDF »
Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems.
M. Amanzio and F. Benedetti (1999)
J. Neurosci. 19, 484-494
   Abstract »    Full Text »    PDF »
Naloxone and Alzheimer's Disease: Cognitive and Behavioral Effects of a Range of Doses.
P. N. Tariot, T. Sunderland, H. Weingartner, D. L. Murphy, M. R. Cohen, and R. M. Cohen (1986)
Arch Gen Psychiatry 43, 727-732
   Abstract »    PDF »
High-Dose Naloxone Infusions in Normals: Dose-Dependent Behavioral, Hormonal, and Physiological Responses.
M. R. Cohen, R. M. Cohen, D. Pickar, H. Weingartner, and D. L. Murphy (1983)
Arch Gen Psychiatry 40, 613-619
   Abstract »    PDF »
Naloxone Dosage.
O. Sugar (1983)
Arch Neurol 40, 189
   Abstract »    PDF »
Organization of endogenous opiate and nonopiate pain control systems.
L. Watkins and D. Mayer (1982)
Science 216, 1185-1192
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)