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Science 10 March 1978:
Vol. 199. no. 4333, pp. 1078 - 1080
DOI: 10.1126/science.305113
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Articles

Science, Vol 199, Issue 4333, 1078-1080
Copyright © 1978 by American Association for the Advancement of Science

articles

Switch in immunoglobulin class production observed in single clones of committed lymphocytes

MR Wabl, L Forni, and F Loor

Mouse spleen cells, after stimulation with lipopolysaccharide, were cloned in culture. After 4 to 5 days, the daughter cells were stained and examined for immunoglobulin class with double immunofluorescent reagents. A switch of the stained color of these cells was observed, implying a switch from imunoglobulin M to immunoglobulin G production in the progeny of a single B cell.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNA Acrobats of the Ig Class Switch.
C. L. Wang and M. Wabl (2004)
J. Immunol. 172, 5815-5821
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