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Science 3 March 1978:
Vol. 199. no. 4332, pp. 991 - 992
DOI: 10.1126/science.203038
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Articles

Science, Vol 199, Issue 4332, 991-992
Copyright © 1978 by American Association for the Advancement of Science

articles

Platelet factor 4: an inhibitor of collagenase

J Hiti-Harper, H Wohl, and E Harper

Human platelet factor 4 (PF4) is known to bind to heparin and inhibit its anticoagulant effect. This factor also inhibits the enzyme collagenase derived from cultured human skin and collagenase extracted from human granulocytes. The addition of heparin to the PF4-collagenase assay system has no effect on the observed inhibition of collagenase. Thus PF4 inhibits collagenase, in addition to neutralizing heparin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of an inhibitor of neovascularization from cartilage.
M. Moses, J Sudhalter, and R Langer (1990)
Science 248, 1408-1410
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