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Science 3 March 1978:
Vol. 199. no. 4332, pp. 990 - 991
DOI: 10.1126/science.203037

Articles

Science, Vol 199, Issue 4332, 990-991
Copyright © 1978 by American Association for the Advancement of Science


articles

Cyclic adenosine monophosphate production by embryonic chick cells

A Robertson, JF Grutsch, and AR Gingle

Cells dissociated from 1-day-old chick embryos produce a pulse of cyclic adenosine monophosphate (cyclic AMP) when stimulated with cyclic AMP. There is a stimulus threshold concentration of about 10(-8) molar cyclic AMP and an upper limit, above which the response is suppressed, of about 6 X 10(-6) molar. The response occurs within 5 seconds of stimulation and corresponds to an average pulse size in the range of 10(7) molecules per cell.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)