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Science 24 February 1978:
Vol. 199. no. 4331, pp. 907 - 909
DOI: 10.1126/science.199.4331.907
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Articles

Inhibition of Carbonic Anhydrase by Anions in the Carbon Dioxide-Bicarbonate System

Y. POCKER 1 and NOBUO TANAKA 1

1 Department of Chemistry, University of Washington, Seattle 98195

Chloride and iodide ions exhibit noncompetitive inhibition of carbon dioxide hydration catalyzed by bovine carbonic anhydrase and competitive inhibition of bicarbonate dehydration. Consideration of the net velocity at equilibrium leads to a satisfactory resolution of the dilemma concerning the different concentrations of such anions required to halve the initial reaction rate for each substrate.

Submitted on March 25, 1977
Revised on October 17, 1977

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Science. ISSN 0036-8075 (print), 1095-9203 (online)