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Science 17 February 1978:
Vol. 199. no. 4330, pp. 804 - 806
DOI: 10.1126/science.203034
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Articles

Science, Vol 199, Issue 4330, 804-806
Copyright © 1978 by American Association for the Advancement of Science

articles

Biologically active pituitary hormones in the rat brain amygdaloid nucleus

ST Pacold, L Kirsteins, S Hojvat, and AM Lawrence

While an attempt was being made to identify the source of the growth hormone releasing factor present in cerebral spinal fluid of man, it was discovered that cells of the rat amygdaloid nucleus, grown in tissue culture, produce a material that is immunologically and chromatographically identical to growth hormone found in the pituitary. Immunoperoxidase staining revealed dense accumulation of the peroxidase-antibody to growth hormone complex in amygdala cells. Significant amounts of growth hormone and adrenocorticotropin could be extracted from this limbic structure. Extracts containing immunoequivalent amounts of growth hormone were measured by bioassay in hypophysectomized rats. Stimulation of the growth of epiphyseal cartilage by extracts of the amygdala was comparable to the stimulation by extracts of anterior pituitary glands. The stimulatory effect of amygdala extracts on adrenal and gonadal size and weight and on growth of thyroid follicular epithelium was also comparable to that of pituitary extracts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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N. D. Aberg, B. Carlsson, L. Rosengren, J. Oscarsson, O. G. P. Isaksson, L. Ronnback, and P. S. Eriksson (2000)
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Regulation of Insulin-Like Growth Factor I (IGF-I) Gene Expression in Brain of Transgenic Mice Expressing an IGF-I-Luciferase Fusion Gene.
P. Ye, Y. Umayahara, D. Ritter, T. Bunting, H. Auman, P. Rotwein, and A. J. D'Ercole (1997)
Endocrinology 138, 5466-5475
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Adrenocorticotropic hormone may be transported directly from the pituitary to the brain.
R Bergland, H Blume, A Hamilton, P Monica, and R Paterson (1980)
Science 210, 541-543
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Pituitary hormones in brain: where, how, and why?.
D. Krieger and A. Liotta (1979)
Science 205, 366-372
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Pituitary-brain vascular relations: a new paradigm.
R. Bergland and R. Page (1979)
Science 204, 18-24
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Telemetered EEG-EOG During Psychotic Behaviors of Schizophrenia.
J. R. Stevens, L. Bigelow, D. Denney, J. Lipkin, A. H. Livermore Jr, F. Rauscher, and R. J. Wyatt (1979)
Arch Gen Psychiatry 36, 251-262
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