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Science 17 February 1978:
Vol. 199. no. 4330, pp. 787 - 788
DOI: 10.1126/science.622569
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Articles

Science, Vol 199, Issue 4330, 787-788
Copyright © 1978 by American Association for the Advancement of Science

articles

Human breast cancer: androgen action mediated by estrogen receptor

DT Zava and WL McGuire

Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses significantly increase both DNA and estrogen-dependent protein synthesis. We therefore propose that androgens stimulate MCF-7 cell growth not through the androgen receptor but rather through the estrogen receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone.
F. Labrie, V. Luu-The, C. Labrie, A. Belanger, J. Simard, S.-X. Lin, and G. Pelletier (2003)
Endocr. Rev. 24, 152-182
   Abstract »    Full Text »    PDF »
Androgen-Induced Inhibition of Proliferation in Human Breast Cancer MCF7 Cells Transfected with Androgen Receptor.
J. Szelei, J. Jimenez, A. M. Soto, M. F. Luizzi, and C. Sonnenschein (1997)
Endocrinology 138, 1406-1412
   Abstract »    Full Text »    PDF »


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