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Science 17 February 1978:
Vol. 199. no. 4330, pp. 786 - 787
DOI: 10.1126/science.622568
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Articles

Science, Vol 199, Issue 4330, 786-787
Copyright © 1978 by American Association for the Advancement of Science

articles

Saturnine gout: lead-induced formation of guanine crystals

WR Farkas, T Stanawitz, and M Schneider

Intravenous injection of a sublethal dose of lead acetate into a domestic pig resulted in a 4.5-fold increase of guanine in the urine, indicating an impairment in the conversion of guanine to xanthine. This impairment is probably due to the inhibition of guanine aminohydrolase (guanase), since the activity of this enzyme is inhibited by Pb2+ (the inhibition constant being 3.0 X 10(-6)M). Postmortem histological examination revealed concretions of crystalline material in the epiphyseal plate of the femoral head. Extraction of the section containing the concretions showed that they were guanine. The relation of these findings to saturnine gout is discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Guanine Deaminase Functions as Dihydropterin Deaminase in the Biosynthesis of Aurodrosopterin, a Minor Red Eye Pigment of Drosophila.
J. Kim, S. I. Park, C. Ahn, H. Kim, and J. Yim (2009)
J. Biol. Chem. 284, 23426-23435
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Cloning and Characterization of Human Guanine Deaminase. PURIFICATION AND PARTIAL AMINO ACID SEQUENCE OF THE MOUSE PROTEIN.
G. Yuan, J. C. Bin, D. J. McKay, and F. F. Snyder (1999)
J. Biol. Chem. 274, 8175-8180
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