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Science 17 February 1978:
Vol. 199. no. 4330, pp. 775 - 776
DOI: 10.1126/science.622565
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Articles

Science, Vol 199, Issue 4330, 775-776
Copyright © 1978 by American Association for the Advancement of Science

articles

L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment

MM Wick

L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.


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