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Science 3 February 1978:
Vol. 199. no. 4328, pp. 542 - 544
DOI: 10.1126/science.564080
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Articles

Science, Vol 199, Issue 4328, 542-544
Copyright © 1978 by American Association for the Advancement of Science

articles

Bone cells: a serum-free medium supports proliferation in primary culture

JK Burns and WA Peck

Bone-cells isolated from embryonic rat calvaria increase in number two-to threefold when cultured at high, but not at low, population densities in a serum-free medium that contains albumin. Cultured cells respond to parathyroid hormone and exhibit a marked rise in alkaline phosphatase activity during proliferation, which suggests the progressive differentiation or preferential growth of osteoblast-like cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria.
E Canalis, W. Peck, and L. Raisz (1980)
Science 210, 1021-1023
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