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Science 27 January 1978:
Vol. 199. no. 4327, pp. 443 - 445
DOI: 10.1126/science.22933
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Articles

Science, Vol 199, Issue 4327, 443-445
Copyright © 1978 by American Association for the Advancement of Science

articles

Dopaminergic inhibition of adrenergic neurotransmission as a model for studies on dopamine receptor mechanisms

OS Steinsland and JP Hieble

Dopamine and apomorphine produced concentration-dependent inhibition of adrenergic neurotransmission in the isolated, perfused, rabbit ear artery. The inhibitory action of both dopamine and apomorphine was competitively antagonized by haloperidol and several other antipsychotic drugs. The calculated affinities of these drugs for the dopaminergic receptor correlate closely with both the pharmacological potencies of these drugs in vivo and their reported potencies as inhibitors of [3H]haloperidol binding to "dopamine receptors" in brain homogenates.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)