Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 January 1978:
Vol. 199. no. 4327, pp. 429 - 431
DOI: 10.1126/science.619463
Prev | Table of Contents | Next

Articles

Science, Vol 199, Issue 4327, 429-431
Copyright © 1978 by American Association for the Advancement of Science

articles

Inherited medullary thyroid carcinoma: a final monoclonal mutation in one of multiple clones of susceptible cells

SB Baylin, SH Hsu, DS Gann, RC Smallridge, and SA Wells Jr

Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes.
J. G. Guillem, W. C. Wood, J. F. Moley, A. Berchuck, B. Y. Karlan, D. G. Mutch, R. F. Gagel, J. Weitzel, M. Morrow, B. L. Weber, et al. (2006)
J. Clin. Oncol. 24, 4642-4660
   Abstract »    Full Text »    PDF »
Genome-Wide Copy Number Imbalances Identified in Familial and Sporadic Medullary Thyroid Carcinoma.
D. J. Marsh, G. Theodosopoulos, K. Martin-Schulte, A.-L. Richardson, J. Philips, H.-D. Roher, L. Delbridge, and B. G. Robinson (2003)
J. Clin. Endocrinol. Metab. 88, 1866-1872
   Abstract »    Full Text »    PDF »
Germline RET 634 Mutation Positive MEN 2A-related C-Cell Hyperplasias Have Genetic Features Consistent with Intraepithelial Neoplasia.
S. J. Diaz-Cano, M. de Miguel, A. Blanes, R. Tashjian, and H. J. Wolfe (2001)
J. Clin. Endocrinol. Metab. 86, 3948-3957
   Abstract »    Full Text »    PDF »
Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression.
L. M. McGregor, B. K. McCune, J. R. Graff, P. R. McDowell, K. E. Romans, G. D. Yancopoulos, D. W. Ball, S. B. Baylin, and B. D. Nelkin (1999)
PNAS 96, 4540-4545
   Abstract »    Full Text »    PDF »
The Molecular Biology of Medullary Thyroid Carcinoma: A Model for Cancer Development and Progression.
B. D. Nelkin, A. C. de Bustros, M. Mabry, and S. B. Baylin (1989)
JAMA 261, 3130-3135
   Abstract »    PDF »
Multiclonal origin of polyps in Gardner syndrome.
S. Hsu, G. Luk, A. Krush, Hamilton SR, and H. Hoover Jr (1983)
Science 221, 951-953
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)