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Science 20 January 1978:
Vol. 199. no. 4326, pp. 319 - 322
DOI: 10.1126/science.202029
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Articles

Science, Vol 199, Issue 4326, 319-322
Copyright © 1978 by American Association for the Advancement of Science

articles

Guanosine 3',5'-monophosphate: a central nervous system regulator of analgesia

ML Cohn, M Cohn, and PH Taylor

The dibutyryl derivative of guanosine 3',5'-monophosphate (cyclic GMP), administered centrally, totally abolishes response to noxious stimuli without depressing the central nervous system. Analgesic properties of the nucleotide are not reversed by naloxone. Microinjected intracerebrally into different sites, dibutyryl cyclic GMP does not mimic the action of morphine. Pharmacological effects of dibutyryl cyclic GMP suggest that endogenous cyclic GMP modulates an inhibitory pain pathway distinct from that on which morphine acts.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)