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Science 20 January 1978:
Vol. 199. no. 4326, pp. 309 - 311
DOI: 10.1126/science.202027
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Articles

Science, Vol 199, Issue 4326, 309-311
Copyright © 1978 by American Association for the Advancement of Science

articles

Pineal serotonin N-acetyltransferase activity: abrupt decrease in adenosine 3',5'-monophosphate may be signal for "turnoff"

DC Klein, MJ Buda, CL Kapoor, and G Krishna

Dispersed pinealocytes have been used to study the role of adenosine 3',5'-monophosphate (cyclic AMP) in the "turnoff" of N-acetyltransferace activity. Activity was first stimulated 100-fold by treating cells with 1-norepinephrine. 1-Propranolol acted stereospecifically to rapidly reverse this, resulting in a 70 percent loss of enzyme activity within 15 minutes. An even more rapid 1-propranolol-induced decreased in cyclic AMP also occurred. This together with the observation that the inhibitory effect of 1-propranolol on N-acetyltransferase was blocked by dibutyryl cyclic AMP and phosphodiesterase inhibitors indicate that an abrupt decrease in cyclic AMP may be the signal for the rapid decrease in pineal N-acetyltransferase activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Proteasomal Proteolysis in the Adrenergic Induction of Arylalkylamine-N-Acetyltransferase in Rat Pinealocytes.
D. L. Terriff, C. L. Chik, D. M. Price, and A. K. Ho (2005)
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Transcription Factors May Frame Aa-nat Gene Expression and Melatonin Synthesis at Night in the Syrian Hamster Pineal Gland.
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Endocrinology 144, 2461-2472
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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters.
V. Simonneaux and C. Ribelayga (2003)
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Melatonin Production: Proteasomal Proteolysis in Serotonin N-Acetyltransferase Regulation.
J. A. Gastel, P. H. Roseboom, P. A. Rinaldi, J. L. Weller, and D. C. Klein (1998)
Science 279, 1358-1360
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The Vascular Smooth Muscle Type I Angiotensin II Receptor mRNA Is Destabilized by Cyclic AMP-Elevating Agents.
X. Wang, G. Nickenig, and T. J. Murphy (1997)
Mol. Pharmacol. 52, 781-787
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Pineal Serotonin N-Acetyltransferase: Expression Cloning and Molecular Analysis.
S. L. Coon, P. H. Roseboom, R. Baler, J. L. Weller, M. A. A. Namboodiri, E. V. Koonin, and D. C. Klein (1995)
Science 270, 1681-1683
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Vertebrate Circadian and Photoperiodic Systems: Role of the Pineal Gland and Melatonin.
H. Underwood and B. D. Goldman (1987)
J Biol Rhythms 2, 279-315
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The psychopharmacology of the human pineal.
S.A. Checkley and S.B.G. Park (1987)
J Psychopharmacol 1, 109-125
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Pineal N-acetyltransferase is inactivated by disulfide-containing peptides: insulin is the most potent.
M. Namboodiri, J. Favilla, and D. Klein (1981)
Science 213, 571-573
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