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Science 20 January 1978:
Vol. 199. no. 4326, pp. 303 - 305
DOI: 10.1126/science.619458
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Articles

Science, Vol 199, Issue 4326, 303-305
Copyright © 1978 by American Association for the Advancement of Science

articles

Nicotine in breast fluid of nonlactating women

NL Petrakis, LD Gruenke, TC Beelen, N Castagnoli Jr, and JC Craig

Using a combination of gas chromatography, mass spectrometry, and selected ion recording techniques, we have identified nicotine and its major metabolite, continine, in the breast fluid of nonlactating women smokers. As little as 25 picograms could be measured by using the deuterated variants, [5',5'-2H]nicotine and [3,3-2H]cotinine, both as internal standards and as carriers in an inverse isotope dilution method.


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