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Science 6 January 1978:
Vol. 199. no. 4324, pp. 71 - 72
DOI: 10.1126/science.199.4324.71
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Articles

Antibody-Dependent Lymphocytotoxicity Induced by Immunoglobulin G from Hodgkin's Disease Splenic Lymphocytes

ROBERT L. LONGMIRE 1, SHERRY RYAN 1, ROBERT McMILLAN 1, AL LIGHTSEY 2, and VICTOR HEATH 2

1 Department of Hematology and Oncology, Scripps Clinic and Research Foundation, La Jolla, California 92037
2 Department of Pathology, U.S. Naval Hospital (Balboa), San Diego, California 92134

Immunoglobulin G, produced in cultures of splenic lymphocytes obtained from patients with Hodgkin's disease, bound to a population of homologous peripheral blood lymphocytes and initiated antibody-dependent cell cytotoxicity in cultures from five out of eight patients. Two patients whose cultures produced negative results had minimal disease; the other was in remission. The target cells appear to be T lymphocytes; the effector cells bear Fc receptors that are inhibited by antigen-antibody complexes. Antibody-dependent cell cytotoxicity events may produce the anergy and lymphopenia often seen in Hodgkin's disease.

Submitted on April 22, 1977
Revised on July 25, 1977


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Flicker Fusion Test and Occupational Toxicology: Performance Evaluation in Workers Exposed to Lead and Solvents.
A. Betta, A. De Santa, C. Savonitto, and F. D'Andrea (1983)
Human and Experimental Toxicology 2, 83-90
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