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Science 23 December 1977:
Vol. 198. no. 4323, pp. 1274 - 1276
DOI: 10.1126/science.337493
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Articles

Science, Vol 198, Issue 4323, 1274-1276
Copyright © 1977 by American Association for the Advancement of Science

articles

Methylphenidate in hyperkinetic children: differences in dose effects on learning and social behavior

RL Sprague and EK Sleator

Methylphenidate (Ritalin) is widely prescribed for hyperkinetic children. This study showed a peak enchancement of learning in children after being given a dose of 0.3 milligram per kilogram of body weight, and a decrement in learning in those given larger doses; social behavior showed the most improvement in children given 1.0 milligram per kilogram. These results had been hypothesized from theoretical dose-response curves which indicate different target behaviors would improve at different doses.


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