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Science 9 December 1977:
Vol. 198. no. 4321, pp. 1063 - 1065
DOI: 10.1126/science.22127
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Articles

Science, Vol 198, Issue 4321, 1063-1065
Copyright © 1977 by American Association for the Advancement of Science

articles

Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues

SY Cech and LJ Ignarro

Mammalian tissues possess the capacity to synthesize cytidine 3',5'-monopHosphate (cyclic CMP) via the enzymatic conversion of cytidine 5'-triphosphate to cyclic CMP by cytidylate cyclase. Cyclic CMP formation occurs best in the presence of manganese or iron, at neutral pH, at 37 degrees C, in the absence of detergents, and with whole tissue homogenate fractions. Thus, mammalian tissues are capable of synthesizing not only cyclic AMP and cyclic GMP, but also cyclic CMP.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytidylate cyclase: possible artifacts in the methodology.
R. Gaion and G Krishna (1979)
Science 203, 672-673
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Cytidine 3',5'-monophosphate phosphodiesterase: decreased activity in the regenerating and developing liver.
M Shoji, N. Brackett, and J. Kuo (1978)
Science 201, 826-828
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