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Science 2 December 1977:
Vol. 198. no. 4320, pp. 951 - 953
DOI: 10.1126/science.201026
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Articles

Science, Vol 198, Issue 4320, 951-953
Copyright © 1977 by American Association for the Advancement of Science

articles

Regions of cerebral ischemia located by pyridine nucleotide fluorescence

FA Welsh, MJ O'Connor, and TW Langfitt

The fluorescence of the reduced form of the endogenous pyridine nucleotide nicotinamide adenine dinucleotide was used to map regions of ischemia in cat brain. A remarkably microheterogeneous pattern of increased fluorescence resulted from a critical level of incomplete cerebral ischemia. The fluorescence pattern suggests that ischemia occurs initially in microwatershed zones between penetrating cerebral arteries.


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Local cerebral glucose metabolism during controlled hypoxemia in rats.
W. Pulsinelli and T. Duffy (1979)
Science 204, 626-629
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