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Science 2 December 1977:
Vol. 198. no. 4320, pp. 944 - 946
DOI: 10.1126/science.337489
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Articles

Science, Vol 198, Issue 4320, 944-946
Copyright © 1977 by American Association for the Advancement of Science

articles

Saccharin and other sweeteners: mutagenic properties

RP Batzinger, SY Ou, and E Bueding

Saccharin preparations commonly distributed as artificial sweeteners exhibited mutagenic activity in bacterial tests. When administered orally to mice, mutagenic activity was demonstrable in the urines of these animals as well as in a host-mediated assay. Highly purified saccharin was not mutagenic in the direct assay, but the urines of mice to which this material had been administered exhibited mutagenic effects on one tester strain (Salmonella typhimurium TA100). Two other sweeteners, neohesperidin dihydrochalcone and xylitol, had no detectable mutagenic activity in any of these assays using his- Salmonella typhimurium strains TA100 or TA98.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selection for Streptococcus mutans with an Altered Xylitol Transport Capacity in Chronic Xylitol Consumers.
L. Trahan and C. Mouton (1987)
Journal of Dental Research 66, 982-988
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Genetic effects of impure and pure saccharin in yeast.
C. Moore and A Schmick (1979)
Science 205, 1007-1010
   Abstract »    PDF »
Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin.
S Mondal, D. Brankow, and C Heidelberger (1978)
Science 201, 1141-1142
   Abstract »    PDF »


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