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Science 2 December 1977:
Vol. 198. no. 4320, pp. 934 - 936
DOI: 10.1126/science.22126
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Articles

Science, Vol 198, Issue 4320, 934-936
Copyright © 1977 by American Association for the Advancement of Science

articles

Cigarette smoke activates guanylate cyclase and increases guanosine 3',5'-monophosphate in tissues

WP Arnold, R Aldred, and F Murad

The gaseous phase of cigarette smoke induced a 2- to 36-fold increase in the activity of guanylate cyclase in supernatant and particulate fractions from various rat and bovine tissues over basal activity. The characteristics of this phenomenon paralleled those of the activation of guanylate cyclase by nitric oxide, which is a component of tobacco smoke.


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Vascular Responses to Extractable Fractions of Ilex paraguariensis in Rats Fed Standard and High-Cholesterol Diets.
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Biol Res Nurs 7, 146-156
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Cell-Specific Expression and Regulation of Soluble Guanylyl Cyclase {alpha}1 and {beta}1 Subunits in the Rat Ovary.
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Biol Reprod 70, 1552-1561
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Nitric oxide inhalation transiently elevates pulmonary levels of cGMP, iNOS mRNA, and TNF-alpha.
T. C. Brady, J. D. Crapo, and R. R. Mercer (1998)
Am J Physiol Lung Cell Mol Physiol 275, L509-L515
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