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Science 28 October 1977:
Vol. 198. no. 4315, pp. 403 - 405
DOI: 10.1126/science.198877
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Articles

Science, Vol 198, Issue 4315, 403-405
Copyright © 1977 by American Association for the Advancement of Science

articles

Hypertension: increase of collagen biosynthesis in arteries but not in veins

K Iwatsuki, GJ Cardinale, S Spector, and S Udenfriend

In two models of hypertension in rats, it was shown that collagen synthesis and deposition are increased in arteries where blood pressure is elevated. By contrast, there were no alterations in any of the markers of collagen synthesis in veins, where blood pressure was only slightly elevated. It would appear that the stimulus for vascular collagen synthesis is provided by a direct effect of the increased pressure on the arterial cells rather than by a humoral factor released into the general circulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Relations of Matrix Remodeling Biomarkers to Blood Pressure Progression and Incidence of Hypertension in the Community.
R. Dhingra, M. J. Pencina, P. Schrader, T. J. Wang, D. Levy, K. Pencina, D. A. Siwik, W. S. Colucci, E. J. Benjamin, and R. S. Vasan (2009)
Circulation 119, 1101-1107
   Abstract »    Full Text »    PDF »
Regulation of cardiovascular collagen synthesis by mechanical load.
J. E. Bishop and G. Lindahl (1999)
Cardiovasc Res 42, 27-44
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Serum Markers of Collagen Type I Metabolism in Spontaneously Hypertensive Rats : Relation to Myocardial Fibrosis.
J. Diez, A. Panizo, M. J. Gil, I. Monreal, M. Hernandez, and J. P. Mindan (1996)
Circulation 93, 1026-1032
   Abstract »    Full Text »
The Emerging Concept of Vascular Remodeling.
G. H. Gibbons and V. J. Dzau (1994)
N. Engl. J. Med. 330, 1431-1438
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