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Science 14 October 1977:
Vol. 198. no. 4313, pp. 199 - 201
DOI: 10.1126/science.905823
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Articles

Science, Vol 198, Issue 4313, 199-201
Copyright © 1977 by American Association for the Advancement of Science

articles

Bovine protoporphyria: the first nonhuman model of this hereditary photosensitizing disease

GR RUTH, S Schwartz, and B Stephenson

Protoporphyria, a photosensitizing disease documented only in humans, was transmitted as a recessive trait to seven female calves. Cutaneous lesions were extensive, and erythrocyte and fecal protoporphyrin concentrations exceeded by far those of human protoporphyria. Average ferrochelatase activity was decreased to one-half of normal in the liver of carriers, and to about one-tenth of normal in liver, kidney, heart, spleen, lung, and marrow of protoporphyrics.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Feline acute intermittent porphyria: a phenocopy masquerading as an erythropoietic porphyria due to dominant and recessive hydroxymethylbilane synthase mutations.
S. Clavero, D. F. Bishop, M. E. Haskins, U. Giger, R. Kauppinen, and R. J. Desnick (2009)
Hum. Mol. Genet.
   Abstract »    Full Text »    PDF »
Bovine Teat Atresia Associated with Horn Fly (Haematobia irritans irritans (L.))-induced Dermatitis.
J. F. Edwards, S. E. Wikse, R. W. Field, C. C. Hoelscher, and D. B. Herd (2000)
Vet. Pathol. 37, 360-364
   Abstract »    Full Text »    PDF »


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