Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 October 1977:
Vol. 198. no. 4312, pp. 62 - 64
DOI: 10.1126/science.897683
Prev | Table of Contents | Next

Articles

Science, Vol 198, Issue 4312, 62-64
Copyright © 1977 by American Association for the Advancement of Science

articles

Striatal efferent fibers play a role in maintaining rotational behavior in the rat

JF Marshall and U Ungerstedt

Rats in which ascending dopamine-containing neurons have been unilaterally destroyed by injections of 6-hydroxydopamine are known to rotate after being injected with apomorphine or L-dopa. The rotation is markedly reduced by either (i) ipsilateral electrocoagulations of the caudate-putamen or internal capsule or (ii) ipsilateral coronal knife cuts immediately rostral to the substantia nigra. Neostriatal efferent fibers, in particular the strionigral projection, appear to be required for the expression of this dopamine-dependent behavior.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease.
R. Sanchez-Pernaute, H. Lee, M. Patterson, C. Reske-Nielsen, T. Yoshizaki, K. C. Sonntag, L. Studer, and O. Isacson (2008)
Brain 131, 2127-2139
   Abstract »    Full Text »    PDF »
Immortalized Dopamine Neurons: A Model to Study Neurotoxicity and Neuroprotection.
E. D. Clarkson, J. Edwards-Prasad, C. R. Freed, and K. N. Prasad (1999)
Experimental Biology and Medicine 222, 157-163
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)