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Science 2 September 1977:
Vol. 197. no. 4307, pp. 999 - 1001
DOI: 10.1126/science.302032
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Articles

Science, Vol 197, Issue 4307, 999-1001
Copyright © 1977 by American Association for the Advancement of Science

articles

Induction of suppressor T cells in systemic lupus erythematosus by thymosin and cultured thymic epithelium

S Horowitz, W Borcherding, AV Moorthy, R Chesney, H Schulte-Wisserman, and R Hong

Patients with systemic lupus erythematosus lacked suppressor T cell function. Suppressor cell activity was induced in cells from many of these patients by incubation with thymosin or cultured thymic epithelium. These results suggest that thymic manipulation may be a useful therapeutic modality in this disease.


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Thymoma associated with systemic lupus erythematosus and immunologic abnormalities.
E Bozzolo, M Bellone, N Quaroni, C Voci, and M G Sabbadini (2000)
Lupus 9, 151-154
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Primary antiphospholipid syndrome emerging following thymectomy for myasthenia gravis: Additional evidence for the kaleidoscope of autoimmunity.
Y. Shoenfeld, M. Lorber, T. Yucel, and H. Yazici (1997)
Lupus 6, 474-476
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Transplantation of Thymic Tissue into Patients With AIDS: An Attempt to Reconstitute the Immune System.
J. M. Dwyer, C. C. Wood, J. McNamara, and B. Kinder (1987)
Arch Intern Med 147, 513-517
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Development of Systemic Lupus Erythematosus After Thymectomy for Myasthenia Gravis: Studies of Suppressor Cell Function.
L. H. Calabrese, J.-F. Bach, T. Currie, D. Vidt, J. Clough, and R. S. Krakauer (1981)
Arch Intern Med 141, 253-255
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Sjogren's Syndrome (Sicca Syndrome): Current Issues.
H. M. MOUTSOPOULOS, T. M. CHUSED, D. L. MANN, J. H. KLIPPEL, A. S. FAUCI, M. M. FRANK, T. J. LAWLEY, and M. I. HAMBURGER (1980)
Ann Intern Med 92, 212-226
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Systemic Lupus Erythematosus: Evolving Concepts.
J. L. DECKER, A. D. STEINBERG, J. L. REINERTSEN, P. H. PLOTZ, J. E. BALOW, and J. H. KLIPPEL (1979)
Ann Intern Med 91, 587-604
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Suppressor Cell Function in Sarcoidosis.
J. S. GOODWIN, R. DeHORATIUS, H. ISRAEL, G. T. PEAKE, and R. P. MESSNER (1979)
Ann Intern Med 90, 169-173
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