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Science 2 September 1977:
Vol. 197. no. 4307, pp. 1001 - 1003
DOI: 10.1126/science.560718
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Articles

Science, Vol 197, Issue 4307, 1001-1003
Copyright © 1977 by American Association for the Advancement of Science

articles

Defective phagocytosis of isolated rod outer segments by RCS rat retinal pigment epithelium in culture

RB Edwards and RB Szamier

Retinal pigment epithelium cultured from normal rats phagocytizes large amounts of rod outer segment fragments isolated from normal rats and from RCS rats with inherited retinal degeneration. Cultured RCS rat pigment epithelium rarely ingests outer segment material, although the cells extend cellular processes around fragments of either type. Both normal and RCS pigment epithelium phagocytize polystyrene spheres. This demonstrates that RCS rat pigment epithelial cells contain a defect in the mechanism for phagocytizing outer segments.


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