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Science 26 August 1977:
Vol. 197. no. 4306, pp. 906 - 908
DOI: 10.1126/science.887929
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Articles

Science, Vol 197, Issue 4306, 906-908
Copyright © 1977 by American Association for the Advancement of Science

articles

Psoralen-DNA photoreaction: controlled production of mono- and diadducts with nanosecond ultraviolet laser pulses

BH Johnston, MA Johnson, CB Moore, and JE Hearst

Samples of DNA which contain adducts of a new psoralen derivative, but no cross-links, have been prepared by irradiating mixtures of DNA and the derivative with single, 15-nanosecond pulses of laser light. Succeeding pulses introduce cross-links. The ability to rapidly and selectively create monoadducts and corss-links may allow the use of psoralens as probes of dynamic processes in living cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Repair of Laser-localized DNA Interstrand Cross-links in G1 Phase Mammalian Cells.
P. A. Muniandy, D. Thapa, A. K. Thazhathveetil, S.-t. Liu, and M. M. Seidman (2009)
J. Biol. Chem. 284, 27908-27917
   Abstract »    Full Text »    PDF »
Sharp Kink of DNA at Psoralen-cross-link Site Deduced from Crystal Structure of Psoralen-Thymine Monoadduct.
S.-H. Kim, S. Peckler, B. Graves, D. Kanne, H. Rapoport, and J.E. Hearst (1983)
Cold Spring Harb Symp Quant Biol 47, 361-365
   Abstract »    PDF »


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