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Science 19 August 1977:
Vol. 197. no. 4305, pp. 780 - 782
DOI: 10.1126/science.407649
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Articles

Science, Vol 197, Issue 4305, 780-782
Copyright © 1977 by American Association for the Advancement of Science

articles

Artificial pancreas using living beta cells:. effects on glucose homeostasis in diabetic rats

WL Chick, JJ Perna, V Lauris, D Low, PM Galletti, G Panol, AD Whittemore, AA Like, CK Colton, and MJ Lysaght

An artificial pancreas consisting of beta cells cultured on synthetic semipermeable hollow fibers was tested in rats with alloxan-induced diabetes. When implanted ex vivo as arteriovenous shunts in the circulatory system these devices lowered concentrations of plasma glucose from 533 to between 110 and 130 milligrams per 100 milliliters, increased concentrations of plasma insulin, and restored intravenous glucose tolerance tests essentially to normal.


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