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Science 19 August 1977:
Vol. 197. no. 4305, pp. 778 - 780
DOI: 10.1126/science.196332
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Articles

Science, Vol 197, Issue 4305, 778-780
Copyright © 1977 by American Association for the Advancement of Science

articles

Dopamine and adenosine 3',5'-monophosphate responses of single mammalian sympathetic neurons

NJ Dun, K Kaibara, and AG Karczmar

Acetylcholine (ACh), dopamine, and dibutyryl-adenosine 3',5'-monophosphate (dbcAMP) were applied iontophoretically to the rabbit superior cervical ganglion cells from triple-barreled micropipettes, and the response was recorded by intracellular techniques. All ganglion cells tested responded to the depolarizing action of ACh, whereas less than half of the cells that responded to ACh were hyperpolarized by dopamine. This effect was blocked by low concentrations of haloperidol. None of the cells examined responded to dbcAMP applied by iontophoresis. Hence, the present result is not consistent with the concept that a cyclic AMP mechanism underlies the hyperpolarizing effect of dopamine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synaptic potentials in sympathetic ganglia: are they mediated by cyclic nucleotides?.
N. Busis, F. Weight, and P. Smith (1978)
Science 200, 1079-1081
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