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Science 29 July 1977:
Vol. 197. no. 4302, pp. 475 - 477
DOI: 10.1126/science.877571
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Articles

Science, Vol 197, Issue 4302, 475-477
Copyright © 1977 by American Association for the Advancement of Science

articles

Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro

JH Greenberg, ME Saunders, and A Mellors

Delta-9-tetrahydrocannabinol (delta9-THC) inhibited the activity of lysolecithin acyl transferase, a membrane-bound lymphocyte enzyme, at concentrations above 1.3 muM. Stimulation of acyl transferase activity by concanavalin A, an early response in lymphocyte activation, was entirely abolished in the presence of delta9-THC.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)