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Science 22 July 1977:
Vol. 197. no. 4301, pp. 385 - 388
DOI: 10.1126/science.560060
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Articles

Science, Vol 197, Issue 4301, 385-388
Copyright © 1977 by American Association for the Advancement of Science

articles

Secondary structure of histones and DNA in chromatin

GJ Thomas Jr and B Prescott

Laser Raman spectroscopy indicates that the inner histones which are bound to DNA in chromatin or in isolated nu bodies are similar in conformation to the inner histones which are dissociated from DNA in high-salt solutions. This structure contains, on the average, 51+/-5% alpha-helix and no substantial beta-sheet conformation. It is proposed that the protein core of the nu body has a high alpha-helix content.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Crystallographic Structure of the Octamer Histone Core of the Nucleosome.
E. N. MOUDRIANAKIS, W. E. LOVE, B. C. WANG, N. G. XUONG, and R. W. BURLINGAME (1985)
Science 229, 1110-1112
   PDF »
Crystallographic structure of the octameric histone core of the nucleosome at a resolution of 3.3 A.
R. Burlingame, W. Love, B. Wang, R Hamlin, H. Nguyen, and E. Moudrianakis (1985)
Science 228, 546-553
   Abstract »    PDF »
Conformational States of Chromatin.
M. Zama, P. N. Bryan, R. E. Harrington, A. L. Olins, and D. E. Olins (1978)
Cold Spring Harb Symp Quant Biol 42, 31-41
   Abstract »    PDF »


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