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Science 22 July 1977:
Vol. 197. no. 4301, pp. 381 - 383
DOI: 10.1126/science.17919
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Articles

Science, Vol 197, Issue 4301, 381-383
Copyright © 1977 by American Association for the Advancement of Science

articles

Stimulation of in vitro translation of messenger RNA by actinomycin D and cordycepin

L Leinwand and FH Ruddle

Actinomycin D and cordycepin were tested for their effect on translation in the wheat germ embryo extract and reticulocyte lysate assays for in vitro protein synthesis. Both drugs were found to stimulate the incorporation of 35S-labeled methionine into protein up to threefold as compared to control assays. This was true for synthesis directed by murine myeloma polyadenylate-containing RNA, tobacco mosaic virus RNA, and endogenous reticulocyte messenger RNA.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)