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Science 15 July 1977:
Vol. 197. no. 4300, pp. 279 - 282
DOI: 10.1126/science.327547
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Articles

Science, Vol 197, Issue 4300, 279-282
Copyright © 1977 by American Association for the Advancement of Science

articles

Macrophage tumor killing: influence of the local environment

JB Hibbs Jr, RR Taintor, HA Chapman Jr, and JB Weinberg

Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.


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The Central Role of CD4+ T Cells in the Antitumor Immune Response.
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Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
J. Hibbs Jr, R. Taintor, and Z Vavrin (1987)
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Macrophage-Mediated Antitumor Activity Induced by Poly(Itaconic Acid-co-Styrene.
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Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages.
W. Johnson, S. Pizzo, M. Imber, and D. Adams (1982)
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Tumor cell killing by phorbol ester--differentiated human leukemia cells.
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Modulation of macrophage tumoricidal capability by components of normal serum: a central role for lipid.
H. Chapman Jr and J. Hibbs Jr (1977)
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